Hydroarylation of Alkenes Using Anilines in Hexafluoroisopropanol

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DOI:10.1021/acscatal.0c00872
Corpus ID: 218926491

@article{Colomer2020HydroarylationOA, title={Hydroarylation of Alkenes Using Anilines in Hexafluoroisopropanol}, author={Ignacio Colomer}, journal={ACS Catalysis}, year={2020}, volume={10}, pages={6023-6029}, url={https://api.semanticscholar.org/CorpusID:218926491}}

Ignacio Colomer
Published 12 May 2020
Chemistry
ACS Catalysis

Providing new methods for the selective functionalization of small molecules is highly desirable, because installing molecular diversity in a desired position, for example, allows one to modulate b...

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The new magnesium-catalyzed reaction allows the use of a wide range of alkynes and anilines with different electronic and steric properties and provides free as well as protected aniline yields with excellent yields.

Friedel-Crafts alkylation of arenes with epoxides promoted by fluorinated alcohols or water.

Guoxing LiJ. Qu

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2010

The stereoselective intra- and intermolecular Friedel-Crafts alkylation of electron-rich arenes with epoxides can take place in refluxing 1,1,1,3,3,3-hexafluoroisopropanol owing to its weak acidity…

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2011

The ubiquity of the biaryl motif in natural products, medicines, and novel materials ensures a constant demand for their efficient and selective synthesis, and it is surprising that few para-selective direct arylation reactions are known.

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2019

An efficient para-alkylation of primary and secondary anilines with a variety of sterically encumbered alkenes using a simple β-diketiminato scandium catalyst is reported. This protocol features 100%…

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